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KMID : 0376219850220030469
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Chonnam Medical Journal
1985 Volume.22 No. 3 p.469 ~ p.489
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Ultrastructure of the Granule-Containing Cells in the Heart of the Mongolian Gerbil
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Abstract
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The fine structure of the granule-containing cells in the heart of 5-hydroxydopamine administrated Mongolian gerbil was studied by electron microscope. The granule-containing cells were located in the subepicardial connective tissue in the vicinity of the sinuatrial and atrioventricular nodes within the interatrial septum, and at the base of aorta and pulmonary artery. They are sparsely distributed in small clusters of about 2,5 cells within or near the cardiac ganglia. The individual cells or cell clusters were covered by the cytoplasm of sheath cells. The granule-containing cells were characterized by the presence of dark-cored vesicle. Other cytoplasmic organelles included abundant mitochondria, rough endoplasmic reticulum, well-developed Golgi apparatus, and widely distributed free ribosome.
In 5-hydroxydopamine-treated Mongolian gerbil, the cytoplasmic organelles of the granule-containing cell showed no detectable morphological alterations.
Two types of axon terminals were differentiated by their vesicular inclusion after 5-hydroxydopamine treatment. One type contained small a granular vesicle which were identified as postganglionic cholinergic axon terminal. The other type contained a majority of small granular vesicles which were classified as adrenergic. Large granular vesicles were seen in the both type of axon terminals. Synaptic contacts between the cholinergic axon terminals and somata of granule-containing cells were observed. In addition, synaptic junction between processes of granule containing cells and dendrite of cardiac ganglion cells were also observed.
This study had shown that the granule-containing cells in the heart of Mongolion gerbil were connector neurons interposed in effector circuits between postganglionic cholinergic axon and dendrite.
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